CLK-2/TEL2 is a conserved component of the nonsense-mediated mRNA decay pathway.
Nonsense-mediated mRNA decay (NMD) controls eukaryotic mRNA quality, inducing the degradation of faulty transcripts.Key players in the NMD pathway were originally identified, through genetics, in Caenorhabditis elegans as smg (suppressor with morphological effect on genitalia) genes.Using forward genetics and fluorescence-based NMD reporters, we re